Countdown :

  • Days

  • Hours

  • Minutes

Countdown :

The 6th Asia Pacific Regional ISSX Meeting Agenda

May 11-14, 2018
Zhejiang University, Hangzhou China

Meeting address:

Meng Minwei Building, College of Pharmaceutical Sciences, Zhejiang University (Zijingang Campus),

No. 866, Yuhangtang Road, West Lake District, Hangzhou City, Zhejiang Province, China

中国浙江省杭州市西湖区余杭塘路866号浙江大学紫金港校区药学院,蒙民伟楼

Hosted by:
International Society for Study of Xenobiotics (ISSX)
Organized by:
Chinese Society for Study of Xenobiotics (CSSX)
Co-Organized by:
College of Pharmaceutical Sciences, Zhejiang University

Proposed Meeting Schedule

Drug Metabolism-based Precision Medicine and Druggability
May 10, Thursday Registration
15:00-22:00 Registration
May 11 Friday Registration
8:00-22:00 Registration-at Meng Minwei Building (蒙民伟楼)
May 11 Friday-Morning

Short Courses

Location: Hall 139

Workshop for Pharmaceutical Industries - ADME/DMPK Evaluation for Supporting Therapeutic Innovation
Concurrent with Short Course 1 and 2
Location: Hall 225
Chairs: Genfu Chen (WuXiAppTec, China) and Sylvia Zhao (Novartis, China)
9:00-9:05 Opening Remark
  SC 1: 9:00-12:00
Mechanistic PK/PD Modeling and Simulation: Steps to Become a PBPK/QSP Modeler
  Workshop 1: 9:00-12:00
Metabolite Evaluations and Mass Balance Studies
  Chairs: Yanyan Zhang (Sanofi, China) and Rukmini Kumar (Vantage Research, India)   Chairs: Frances Wang, (J & J, China) and Mandy Xu (Pharmaron, China)
9:00-9:50 Jiansong Yang (Mosim, Shanghai)
An Introduction to Physiologically Based Pharmacokinetic (PBPK) Modeling
9:05-9:45 Thomas Ballie (University of Washington, USA)
Reactive metabolite
9:50-10:40 Rukmini Kumar (Vantage Research, India)
Overview of QSP applications in drug development and regulatory outlook
9:45-10:30 Mingshe Zhu (WuXi AppTec, China)
Mass Balance Study–Design, Data Analysis, Implicationsfor Dosing, and Labeling Recommendations
10:40-11:30 Yan-Yan Zhang & Yoshihisa Shitara (Sanofi Shanghai and Tokyo)
General equations to construct the systems model, and MATLAB Simbiology software orientation
10:30-11:15 Jeff Zhang (Novartis, China) Metabolic profiling and mass balance study in preclinical species and human
11:30-12:00 Panel discussion and Q&A 11:15-12:00 Zheming Gu (Value Pharmaceutical Services Co., Ltd. China) 
Metabolite Screening and Evaluation in Early Drug Clinic Trials




12:00-13:00 Working Lunch 12:00-13:00

Haihua Yu-Huayi Molecular Imaging Sponsored Lunch Seminar (Location: Hall 225)

Application of Radionuclide Molecular Imaging Technology in Drug Discovery

May 11 Friday-Afternoon SC 2: 13:00-16:00  (Location: Hall 139)
Application of PBPK modeling in drug discovery and development: case studies
 May 11  Friday-Afternoon Workshop 2: 13:00-15:15(Location: Hall 225)
Understanding the 2017 FDA DDI Guidance
  Chairs: Houfu Liu (Sanofi, China) and Michael Bolger (SimulationPlus, US)   Chairs: Shiew-Mei Huang-INVITED (Maryland, USA) and Xiuwen Liu (Shouzhou Xishan Zhongke, China) 
13:00-13:45 Chuang Lu (Sanofi, US)
Application of Physiologically-based Pharmacokinetic Modeling and Simulation in Prediction of Human PK and Drug-drug Interactions.
13:00-13:40

Dan Cui (Morphic Therapeutic, USA) 

Interpretation and Integration for Time-Dependent Inhibition in New FDA DDI 2017 Draft Guidance - from In Vitro Experiment, PBPK Modeling to Clinical

13:45-14:30 Hongcan Ren (Hutchison Pharma, Shanghai)
Modeling and simulation of double peaks in dogs using a modified PBPK model-mechanism exploring and clinical risk evaluation.
13:40-14:20 Hongjian Zhang (Suzhou University, China)
Understanding and applying 2017 USFDA DDI guidance - Case Studies
14:30-15:15 Noriko Okudaira (DAIICHI SANKYO, Japan)
Application of PBPK model analysis to oncology drug development.
14:20-15:00 Sylvia Zhao (Novartis, China)
DDI:clinical aspects
15:15-16:00 Michael B. Bolger (Simulation Plus, US)
Discovery PBPK: How to estimate the expected accuracy of ISIVE and IVIVE for new chemical entities.

Workshop 3: 15:45-18:00 

Biologics and Transporter

16:00-16:30 Panel discussion and Q&A  

Chairs: Guorong Fan (Shanghai 1st People’s Hospital, China) and 

Buyun Chen (Genentech, USA) 

 15:00-15:40

Yuanguo Cheng (National Shanghai Center for Drug Safety Evaluation, China) 

PK Evaluation for Biologics –Challenges and Solutions

16:30-17:30 Career Development for Students and Young Scientists:
Session with a select group from Industry and Academia on career paths / how to interview / write a winning CV
15:40-16:20 Jing Shi (WuXiAppTec, China)
Bioanalytical Strategy for clinical trials


Tom Baillie, Zhuohan Hu, Mike Sinz, John Miners, Bill Smith, Su Zeng, Jasminder Sahi, Kelly Dong and any other faculty who can be there
16:20-17:00 Buyun Chen (Genentech, USA)        
Quantitative evaluation of drug transporter activities - Case Studies
17:00-17:40

Shiew-Mei Huang- (Maryland, USA)   

Evaluation of transporter-based drug-drug interactions

17:40- 18:40

Special Seminar - Drug Regulatory and Administration in China

Co-Chairs: Dafang Zhong, Su Zeng

Speakers: Alex Xu (CSDA), Qingli Wang (CSDA)

18:40- 18:50 Closing remark
17:40- 18:50 All attendees move to Hall 225 on second floor of Meng Minwei Building to attend Special Seminar - Drug Regulatory and Administration in China, by CSDA

19:00-20:30 Dinner for workshop attendees and faculty 18:30-20:30 Dinner for workshop attendees and faculty
May 12 Saturday-Morning Keynote Lectures /Sessions(Location: Hall 225)
08:30-08:45 Opening Ceremony (5 mins each)
·  Welcome by Su Zeng + Jasminder Sahi
·  Opening words by Zhuohan HU-VP of CSSX 
·  Opening words by Tom Baillie-ISSX chair
  Keynote Lectures
Chairs: Su Zeng and Jasminder Sahi
     
8:45-9:35 Tom Baillie (Univ Washington USA and Chair ISSX)
Targeted Covalent Drugs and the Promise of Personalized Medicine
9:35-10:25 Haiping Hao (China Pharamceutical University, Nanjing)
Haiping Hao (China Pharamceutical University, Nanjing)
10:25-11:00 Group Photo
11:00-12:00 Poster session
12:00-13:00

Sumito Ito-GenoMembrane

sponsored session over Lunch (Location: Hall 225)

Involvement of the bile salt export pump (BSEP) in drug induced liver injury

 


Ming Yao (BMS, USA)-Sciex China sponsored session over Lunch 

Identification of Biotransformation-Mediated Modification of Endogenous Proteins and Biologics Using HRMS, Background Subtraction and PEAKs

May 12 Saturday-Afternoon Session 1 (13:00 - 17:00) (Location: Hall 225)   Session 2 (13:30 - 17:00) (Location: Hall 139)
In vivo Function and Regulation of Drug
Transporters
  ADMET of Drugs and Chemicals
  Chairs: Yuichi Sugiyama & Wooin Lee   Chairs: Bill Smith and Sylvia Zhao
13:00-13:30 Hiroyuki Kusuhara (University of Tokyo, Japan)
Quantitative assessment of in vivo drug transporter activities using endogenous substrates
  Jim Halpert (Univ Connecticut, USA)
Implications of human P450 structures for drug design
13:30-14:00 Wooin Lee (Seoul National University, S.Korea)  
Complexity and Diversity in SLCO Transporters, via Epigenetic and Splicing Regulation 
  Xinxin Ding (University Albany, USA)
Utility of transgenic mice for identification of biomarkers and metabolism-mediated toxicological mechanisms
14:00-14:30

Yoshihisa Shitara (Sanofi, Tokyo)

Time-dependent and long-lasting inhibition of OATP transporters

  Bill Smith (Gilead, USA) 
From Enzymology to Human ADME: Case study of a disproportionate metabolite. 
14:30-15:00 Kazuya Maeda (Univ of Tokyo, Japan) 
Use of “Extended Clearance Concept” to predict complex DDI from in vitro metabolism and transporter Data; focusing on the transporters in the liver"
  Mike Zientek (Takeda, USA)
Unraveling the contribution of aldehyde oxidase to drug clearance:  getting closer to an elusive parameter.
15:00-15:30

Hua Li (Beijing Institute of Pharmacology and Toxicology, China)

Role of P-glycoprotein in BBB penetration and respiratory toxicity of opioid drugs

 

Aiming Yu (UC Davis, USA)

MicroRNAs in the regulation of DMPK



15:30-15:45

Young Speaker-(Wenjun Chen)

MODELING THE PHARMACOKINETIC/PHARMACODYNAMIC INTERACTION BETWEEN DOCETAXEL AND CABOZANTINIB IN THE TREATMENT OF PROSTATE CANCER IN MICE

 

Young Speaker-(Ping Wang)

SENSITIVE DETECTION OF CATECHOL-O-METHYLTRANSFERASE ACTIVITY AND BIOLOGICAL IMAGING WITH FLUORESCENCE PROB

  ISSX Asia Pacific Awards Awards (Location: Hall 225)   

Presented by Tom Baille (ISSX Chair)  
15:45-16:30 Asia Pacific Scientific Achievement Award: Tetsuya Terasaki (Tohoku University, Japan)
Transporter Proteomics of the CNS Barriers
 
16:30-17:15

Asia Pacific New Investigator Award: Huachung Bi (Sun Yat-sen University, China)

PXR/p53-ME-TP axis in liver metabolism and hepatoprotection

 
17:15-18:15 Poster Session
18:15-20:00 Welcome Reception-Banquet
May 13 Sunday-Morning    
8:30-9:20 Keynote lecture(Location: Hall 225)
Chair: Zhuohan Hu (RILD)
Yuichi Sugiyam (RIKEN Institute, Japan)
Role of Transporters in pharmacokinetics (PK)/ pharmacodynamics (PD )/ toxicodynamics (TD)
  Session 3 (9:30 -12:00 )(Location: Hall 225) Session 4 (9:30 -12:00 )(Location: Hall 139)
  Personalized Medicine - Roles of Omics and Disease States Drug Interactions and Liver Injury
  Chairs: John Miners & Min Huang Chairs: Mike Sinz & Eric Chan
9:30-10:00 Magnus Ingelman Sundberg (Karolinska Instuitute, Sweden)
Predictive pharmacogenomic biomarkers for personalized medicine tomorrow
Mike Sinz (BMS, India)
Drug drug interactions: Enzyme Induction
10:00-10:30 Min Huang (Sun Yat-sen University, China) 
Pharmacogenomics-based personalized medicine
Eric Chan (National Univ of Singapore)
PBPK-modeling of complex DDIs between rivaroxaban and amiodarone

10:30-11:00

John O. Miners (Flint Univ, Australia) 
The role of the kidney in drug metabolic clearance: Renal drug metabolism and the effects of impaired renal function on non-renal drug metabolic clearance


Wen Xie (Univ of Pittsburgh, USA)
Disease effect on liver drug metabolism
11:00-11:30

Chonlaphat Sukasem (Mahidol University, Thailand)

Pharmacogenetic profiling in Han Chinese population using whole genome sequencing

Li Wang (University of Connecticut, USA)
Disruption of mitochondria glucose oxidation pathway sensitizes liver to acute injury
11:30-11:45

Young Speaker- (Jia Guo)

Pharmacogenetic profiling in Han Chinese population using whole genome sequencing

Young Speaker-(Yiming Jiang)

Pregnane X receptor regulates liver size and liver cell fate via the activation of yes-associated protein

11:45-12:00

Gold sponsor speaker, Xin Zhang (Wuxi)

Comprehensive Global DMPK-PD Platform for Drug & Biologics Advancement

Silver Sponsor-Song Yuling (Shimadzu)

Application  of new technology in the field of DMPK

 


12:00-13:00

George Zhang-Corning Gentest Sponsored Session over lunch

Strategies for Cytochrome P450 Induction Testing and Alignment with Recent FDA Guidance and Industry Perspective

Mingshe Zhu, Niusheng Xu-Thermofisher Sponsored Session over lunch

Compound Discoverer's application in drug metabolism research

13:00-14:00 Poster Sessions
May 13 Sunday-Afternoon  (Location: Hall 225)  (Location: Hall 139)
  Session 5 (13:00 - 15:30) Session 6 (13:00 - 15:30)
  Drug Interactions and Regulatory Guidance ADMET of Herbal Medicine
  Chairs: Dafang Zhong and Shiew-Mei Huang Chairs: Ge Lin and Chuan Li
13:00-13:30 Shiew-Mei Huang-INVITED (Maryland, USA)
Evaluation of drug-drug interactions in drug development
Ge Lin (Chinese University of Hong Kong)
CYP-mediated metabolic activation and pyrrole-protein adduct formation—the cause and biomarker of pyrrolizidine alkaloid N-oxide-induced herbal hepatotoxicity
13:30-14:00 Dafang Zhong (Chinese Academy of Sciences) 
Clinical trials using radiolabeled drugs - guidance and application
Jiang Zheng (Guizhou Medical University/Shenyang Pharmaceutical University China)
Metabolism-based hepatotoxicity of furanoterpenoids
14:00-14:30 Lu Chuang (Sanofi USA) 
How PBPK modeling can be leveraged for drug drug interactions 
Chuan Li (Chinese Academy of Sciences, Shanghai)
Role of the herbal medicine in drug interactions: perpetrator and victim
14:30-15:00 Hong Shen (BMS USA) 
Comparative evaluation of coproporphyrins I and III with other endogenous compounds as markers of OATP inhibition in healthy subjects
Aik Jiang LAU (National University of Singapore)
Transcriptional Regulation of Drug-Metabolizing Enzymes by Natural Products
15:00-15:15 Young speaker-(Eleanor Cheong)
Slow and tight binding inhibition kinetics of CYP17A1 by abiraterone and its active metabolite

Young speaker-Lihuan Guan

Effects of carnitine palmitoyltransferases on cancer cellular senescence

 

 

 
15:15-15:45 Young Scientist Awards for best poster presentation (Hall 225)
  Round Table Discussions
 16:00-17:00 Discussion 1: Impact of recent CFDA guidances on drug development (Dafang Zhong, Sylvia Zhou) Discussion 2: Bionalysis of Biologics - challenges and triumphs (Kelly Dong)
 17:00-18:00 Discussion 3: FDA DDI Guidance 2017 and impact on drug development (Shiew-Mei Huang, Mike Sinz and Bill Smith) Discussion 4:  Clinical Pharmacology for supporting the NDA (Xuening Li and Jiansong Yang)
18:30 Buffet
May 14 Monday (Location: Hall 225) (Location: Hall 139)
  Session 7 (9:00-10:15) Session 8 (9:00-10:15)
  Evolving topics in drug metabolism Drug metabolism mediated efficacy and adverse effects
  Chairs: Lushan Yu and Xiaomei Zhuang Chairs: Yong Hee Choi and Cai-sheng Wu
9:00-9:25 Ru Yan (University of Macau)
Application of targeted metabolomics and 16S microbial profiling in PK-PD study of herbal medicines: case study of Ginseng
Young Hee Choi (Dongguk University, South Korea)
Drug interaction of metformin and Scutellariae radix in mice
9:25-9:50 Dongyang Liu (Peking Union Medical College Hospital)
Integrated modeling and simulation in support of early clinical development of new drugs in China: case studies
Xiaoqiang Xiang (Fudan University, China) 
Application of PBPK in patient treatment to improve efficacy
9:50-10:15 Lushan Yu (Zhejiang University, China)
Epigenetic activation of the drug transporters in cancer cells
Lan Tang (Southern Medical University, China)
Regulation of metabolic enzymes by oridonin and its detoxification effect on LPS-induced liver injury based on RNA-seq/WGCNA analysis
 
  Session 9 (10:15 - 11:30) Session 10 (10:15 - 11:30)
  Application of advanced drug metabolism models Analytical technology for ADME studies of new drug platforms 
  Chairs:  Sandhya Mandlekar and Yan Yang Chairs: Mingshe Zhu and Kenji Yahata
10:15-10:40 Xin Wang (East China Normal University)
Characterization and application of novel P450 knockout rat models
Haifeng Song (Beijing National Proteomics Research Center)
Disposition of cell  therapeutics: Analytical strategy and methods
10:40-11:05 Sandhya Mandlekar (BMS in India)
Animal Models in the prediction of drug-drug interaction potential of new chemical entities
Kenji Yahata (Sanofi Japan)
Direct quantitation of drugs in organelles from living cell by mass-spectrometry
11:05-11:30 Guangbao Ge (Shanghai University of Chinese Medicine)
Optical probe substrates for drug metabolizing enzymes:design principle and applications
Mingshe Zhu (MassDefect Technologies, USA)
Novel approach for study of exposure and disposition of herbal medicines



11:30-11:45 Closing Ceremony
  Closing words by Zeng Su and Zhuohan Hu
  Closing words by CSSX President
  Closing words by ISSX President

The 6th Asia Pacific Regional ISSX Meeting Agenda

May 11-14, 2018
Zhejiang University, Hangzhou China

Meeting address:

Meng Minwei Building, College of Pharmaceutical Sciences, Zhejiang University (Zijingang Campus),

No. 866, Yuhangtang Road, West Lake District, Hangzhou City, Zhejiang Province, China

中国浙江省杭州市西湖区余杭塘路866号浙江大学紫金港校区药学院,蒙民伟楼

Hosted by:
International Society for Study of Xenobiotics (ISSX)
Organized by:
Chinese Society for Study of Xenobiotics (CSSX)
Co-Organized by:
College of Pharmaceutical Sciences, Zhejiang University

Proposed Meeting Schedule

Drug Metabolism-based Precision Medicine and Druggability
May 10, Thursday Registration
15:00-22:00 Registration
May 11 Friday Registration
8:00-22:00 Registration-at Meng Minwei Building (蒙民伟楼)
May 11 Friday-Morning

Short Courses

Location: Hall 139

Workshop for Pharmaceutical Industries - ADME/DMPK Evaluation for Supporting Therapeutic Innovation
Concurrent with Short Course 1 and 2
Location: Hall 225
Chairs: Genfu Chen (WuXiAppTec, China) and Sylvia Zhao (Novartis, China)
9:00-9:05 Opening Remark
SC 1: 9:00-12:00
Mechanistic PK/PD Modeling and Simulation: Steps to Become a PBPK/QSP Modeler
Chairs: Yanyan Zhang (Sanofi, China) and Rukmini Kumar (Vantage Research, India)
9:00-9:50 Jiansong Yang (Mosim, Shanghai)
An Introduction to Physiologically Based Pharmacokinetic (PBPK) Modeling
9:50-10:40 Rukmini Kumar (Vantage Research, India)
Overview of QSP applications in drug development and regulatory outlook
10:40-11:30 Yan-Yan Zhang & Yoshihisa Shitara (Sanofi Shanghai and Tokyo)
General equations to construct the systems model, and MATLAB Simbiology software orientation
11:30-12:00 Panel discussion and Q&A
12:00-13:00 Sponsored Lunch Seminar (Location: Hall 223)-Open
Workshop 1: 9:00-12:00
Metabolite Evaluations and Mass Balance Studies
Chairs: Frances Wang, (J & J, China) and Mandy Xu (Pharmaron, China)
9:05-9:45 Thomas Ballie (University of Washington, USA)
Reactive metabolite
9:45-10:30 Mingshe Zhu (WuXi AppTec, China)
Mass Balance Study–Design, Data Analysis, Implicationsfor Dosing, and Labeling Recommendations


10:30-11:15 Jeff Zhang, (Novartis, China) Metabolic profiling and mass balance study in preclinical species and human
11:15-12:00 Zheming Gu (Value Pharmaceutical Services Co., Ltd. China)
Metabolite Screening and Evaluation in Early Drug Clinic Trials
12:00-13:00 华益分子影像研究院 Sponsored Lunch Seminar (Location: Hall 139)
May 11 Friday-Afternoon
SC 2: 13:00-16:00 (Location: Hall 139)
Application of PBPK modeling in drug discovery and development: case studies
Chairs: Houfu Liu (Sanofi, China) and Michael Bolger (SimulationPlus, US)
13:00-13:45 Chuang Lu (Sanofi US)
Application of Physiologically-based Pharmacokinetic Modeling and Simulation in Prediction of Human PK and Drug-drug Interactions.
13:45-14:30 Hongcan Ren (Hutchison Pharma, Shanghai)
Modeling and simulation of double peaks in dogs using a modified PBPK model-mechanism exploring and clinical risk evaluation.
14:30-15:15 Noriko Okudaira (DAIICHI SANKYO, Japan)
Application of PBPK model analysis to oncology drug development.
15:15-16:00 Michael B. Bolger (Simulation Plus, US)
Discovery PBPK: How to estimate the expected accuracy of ISIVE and IVIVE for new chemical entities.
16:00-16:30 Panel discussion and Q&A
16:30-17:30 Career Development for Students and Young Scientists:
Session with a select group from Industry and Academia on career paths / how to interview / write a winning CV
Tom Baillie, Zhuohan Hu, Mike Sinz,  John Miners, Bill Smith, Su Zeng, Jasminder Sahi, Kelly Dong and any other faculty who  can be there
17:40- 18:50 All attendees move to Hall 225 on second floor of Meng Minwei Building to attend Special Seminar - Drug Regulatory and Administration in China, by CSDA
19:00-20:30 Dinner for workshop attendees and faculty
Workshop 2: 13:00-15:15 (Location: Hall 225)
Understanding the 2017 FDA DDI Guidance
Chairs: Shiew-Mei Huang-INVITED (Maryland, USA)and Xiuwen Liu (Shouzhou Xishan Zhongke, China)
13:00-13:45 Dan Cui (Morphic Therapeutic, USA)                                                                                                                                                                  Interpretation and Integration for Time-Dependent Inhibition in New FDA DDI 2017 Draft Guidance - from In Vitro Experiment, PBPK Modeling to Clinical
13:45-14:20 Hongjian Zhang (Suzhou University, China)
Understanding and applying 2017 USFDA DDI guidance - Case Studies
14:20-15:00 Sylvia Zhao (Novartis, China)
DDI:clinical aspects


Workshop 3: 15:45-18:00
Biologics and Transporter
Chairs: Guorong Fan (Shanghai 1st People’s Hospital, China) Buyun Chen (Genentech, USA) 
15:00-15:40 Yuanguo Cheng (National Shanghai Center for Drug Safety Evaluation, China) 
PK Evaluation for Biologics –Challenges and Solutions
15:40-16:20 Jing Shi (WuXiAppTec, China)
Bioanalytical Strategy for clinical trials
16:20-17:00 Buyun Chen (Genentech, USA) 
Quantitative evaluation of drug transporter activities - Case Studies
17:00-17:40

Shiew-Mei Huang-INVITED (Maryland, USA)  

Evaluation of transporter-based drug-drug interactions

17:40- 18:40

Special Seminar - Drug Regulatory and Administration in China

Co-Chairs: Dafang Zhong, Su Zeng

Speakers: Alex Xu (CSDA), Qingli Wang (CSDA)

18:40- 18:50 Closing remark
18:30-20:30 Dinner for workshop attendees and faculty
May 12 Saturday-Morning
Keynote Lectures /Sessions (Location: Hall 225)
08:30-08:45 Opening Ceremony (5 mins each)
·  Welcome by Su Zeng + Jasminder Sahi
·  Opening words by Zhuohan HU-VP of CSSX 
·   Opening words by Tom Baillie-ISSX chair
Keynote Lectures
Chairs: Su Zeng and Jasminder Sahi
8:45-9:35 Tom Baillie (Univ Washington USA and Chair ISSX)
Targeted Covalent Drugs and the Promise of Personalized Medicine
9:35-10:25 Haiping Hao (China Pharamceutical University, Nanjing)
Haiping Hao (China Pharamceutical University, Nanjing)
10:25-11:00 Group Photo
11:00-12:00 Poster session
12:00-13:00

ponsored session over Lunch (Location: Hall 225)

Involvement of the bile salt export pump (BSEP) in drug induced liver injury

Ming Yao (BMS, USA)-Sciex China sponsored session over Lunch (Location: Hall 139)

Identification of biotransformation-mediated modification of endogenous proteins and biologics using HRMS, background subtraction and PEAKs

May 12 Saturday-Afternoon
Session 1 (13:00 - 17:00) (Location: Hall 225)
In vivo Function and Regulation of Drug Transporters
Chairs: Yuichi Sugiyama & Wooin Lee
13:00-13:30 Hiroyuki Kusuhara (University of Tokyo, Japan)

Quantitative assessment of in vivo drug transporter activities using endogenous substrates
13:30-14:00

Wooin Lee (Seoul National University, S.Korea)

Complexity and Diversity in SLCO Transporters, via Epigenetic and Splicing Regulation  

14:00-14:30 Yoshihisa Shitara (Sanofi, Tokyo)
Time-dependent and long-lasting inhibition of OATP transporters
14:30-15:00

Kazuya Maeda (Univ of Tokyo, Japan) 

Use of “Extended Clearance Concept” to predict complex DDI from in vitro metabolism and transporter Data; focusing on the transporters in the liver"


 
15:00-15:30

Hua Li (Beijing Institute of Pharmacology and Toxicology, China)

Role of P-glycoprotein in BBB penetration and respiratory toxicity of opioid drugs

15:30-15:45

Young Speaker-(Wenjun Chen)

MODELING THE PHARMACOKINETIC/PHARMACODYNAMIC INTERACTION BETWEEN DOCETAXEL AND CABOZANTINIB IN THE TREATMENT OF PROSTATE CANCER IN MICE



Session 2 (13:30 - 17:00)(Location: Hall 139)
ADMET of Drugs and Chemicals
Chairs: Bill Smith and Sylvia Zhao
13:00-13:30 Jim Halpert (Univ Connecticut, USA)
Implications of human P450 structures for drug design
13:30-14:00 Xinxin Ding (University Albany, USA)
Utility of transgenic mice for identification of biomarkers and metabolism-mediated toxicological mechanisms
14:00-14:30

Bill Smith (Gilead, USA)

From Enzymology to Human ADME: Case study of a disproportionate metabolite.


14:30-15:00 Mike Zientek (Takeda, USA)
Unraveling the contribution of aldehyde oxidase to drug clearance: getting closer to an elusive parameter.
15:00-15:30 Aimin Yu (UC Davis, USA)
MicroRNAs in the regulation of DMPK
15:30-15:45

Young Speaker- (Ping Wang)

SENSITIVE DETECTION OF CATECHOL-O-METHYLTRANSFERASE ACTIVITY AND BIOLOGICAL IMAGING WITH FLUORESCENCE PROB


ISSX Asia Pacific Awards Awards (Location: Hall 225) 

Presented by Tom Baille (ISSX Chair)
15:45-16:30

Asia Pacific Scientific Achievement Award: 

Tetsuya Terasaki (Tohoku University, Japan)

Transporter Proteomics of the CNS Barriers



16:30-17:15

Asia Pacific New Investigator Award:

Huichang Bi (Sun Yat-sen University, China)

PXR/p53-ME-TP axis in liver metabolism and hepatoprotection

17:15-18:15 Poster Session 
18:15-20:00 Welcome Reception-Banquet
May 13 Sunday-Morning
8:30-9:20 Keynote lecture (Location: Hall 225)
Chair: Zhuohan Hu (RILD)
Yuichi Sugiyam (RIKEN Institute Japan)
Role of Transporters in pharmacokinetics (PK)/ pharmacodynamics (PD )/ toxicodynamics (TD)
Session 3 (9:30 -12:00 )(Location: Hall 225)
Personalized Medicine - Roles of Omics and Disease States
Chairs: John Miners & Min Huang
9:30-10:00 Magnus Ingelman Sundberg (Karolinska Instuitute, Sweden)
Predictive pharmacogenomic biomarkers for personalized medicine tomorrow
10:00-10:30 Min Huang (Sun Yat-sen University, China)
Pharmacogenomics-based personalized medicine 
   
10:30-11:00

John O. Miners (Flint Univ, Australia)

The kidney and drug metabolic clearance: Renal drug metabolism and the effects of chronic kidney disease on non-renal drug clearance

11:00-11:30 Chonlaphat Sukasem (Mahidol University, Thailand)
Pharmacogenomics of Severe Cutaneous Adverse Reactions: from Research to Clinical Implementation


11:30-11:45

Young Speaker-(Jia Guo)

Pharmacogenetic profiling in Han Chinese population using whole genome sequencing

11:45-12:00

Gold sponsor speaker, Xin Zhang (Wuxi)

Comprehensive Global DMPK-PD Platform for Drug & Biologics Advancement

12:00-13:00

George Zhang-Corning Sponsored Session over lunch

Strategies for Cytochrome P450 Induction Testing and Alignment with Recent FDA Guidance and Industry Perspective

13:00-14:00 Poster Sessions
Session 4 (9:30 -12:00 )(Location: Hall 139)
Drug Interactions and Liver Injury
Chairs: Mike Sinz & Eric Chan
9:30-10:00 Mike Sinz (BMS, India)
Drug drug interactions: Enzyme Induction
10:00-10:45 Eric Chan (National Univ of Singapore)
PBPK-modeling of complex DDIs between rivaroxaban and amiodarone


10:45-11:15 Wen Xie (Univ of Pittsburgh, USA)
Disease effect on liver drug metabolism
11:00-11:30 Li Wang (University of Connecticut, USA)
Disruption of mitochondria glucose oxidation pathway sensitizes liver to acute injury
11:30-11:45

Young Speaker- (Yiming Jiang)

Pregnane X receptor regulates liver size and liver cell fate via the activation of yes-associated protein

11:45-12:00

Silver Sponsor Speaker-Song Yuling (Shimadzu)

Application of new technology in the field of DMPK



12:00-13:00

Mingshe Zhu, Niusheng XuThermofisher Sponsored Session over lunch

Compound Discoverer's application in drug metabolism research

13:00-14:00 Poster Sessions
May 13 Sunday-Afternoon
Session 5 (13:00 - 15:30)(Location: Hall 225)
Drug Interactions and Regulatory Guidance
Chairs: Dafang Zhong and  Shiew-Mei Huang-INVITED
13:00-13:30 PK Evaluation for Biologics –Challenges and Solutions
Scientific perspective on the evaluation of transporter-based drug-drug interactions
13:30-14:00 Dafang Zhong (Chinese Academy of Sciences)  
Clinical trials using radiolabeled drugs - guidance and application
14:00-14:30 Lu Chuang (Sanofi USA)
How PBPK modeling can be leveraged for drug drug interactions 
14:30-15:00

Hong Shen (BMS USA) 

Comparative evaluation of coproporphyrins I and III with other endogenous compounds as markers of OATP inhibition in healthy subjects


 

15:00-15:15

Young speaker-(Eleanor Cheong)

Slow and tight binding inhibition kinetics of CYP17A1 by abiraterone and its active metabolite

 15:15-15:45 Young Scientist Awards for best poster presentation (Hall 225)

Round Table Discussions
16:00-17:00 Discussion 1: Impact of recent CFDA guidances on drug development (Dafang Zhong, Sylvia Zhou)
 17:00-18:00 Discussion 3:  FDA DDI Guidance 2017 and impact on drug development (Shiew-Mei Huang, Mike Sinz and Bill Smith)
18:30 Buffet
Session 6 (13:00 - 15:30)(Location: Hall 139)
ADMET of Herbal Medicine
Chairs: Ge Lin and Chuan Li
13:00-13:30 Ge Lin (Chinese University of Hong Kong)
CYP-mediated metabolic activation and pyrrole-protein adduct formation—the cause and biomarker of pyrrolizidine alkaloid N-oxide-induced herbal hepatotoxicity
13:30-14:00 Jiang Zheng (Guizhou Medical University/Shenyang Pharmaceutical University, China)
Metabolism-based hepatotoxicity of furanoterpenoids
14:00-14:30 Chuan Li (Chinese Academy of Sciences, Shanghai)
Role of the herbal medicine in drug interactions: perpetrator and victim


14:30-15:00 Aik Jiang LAU (National University of Singapore)
Transcriptional Regulation of Drug-Metabolizing Enzymes by Natural Products


 

Young speaker-(Lihuan Guan)

Effects of carnitine palmitoyltransferases on cancer cellular senescence

  Awards for best abstracts and young speakers (Hall 225)

Round Table Discussions
 16:00-17:00 Discussion 2: Bionalysis of Biologics - challenges and triumphs (Kelly Dong)
 17:00-18:00 Discussion 4: Clinical Pharmacology for supporting the NDA (Xuening Li and Jiansong Yang)
18:30 Buffet
May 14 Monday Sunrise Forum Session
Session 7 (9:00-10:15)(Location: Hall 225)
Evolving topics in drug metabolism
Chairs: Lushan Yu and Xiaomei Zhuang
9:00-9:25

Ru Yan (University of Macau)

Application of targeted metabolomics and 16S microbial profiling in PK-PD study of herbal medicines: case study of Ginseng

9:25-9:50 Dongyang Liu (Peking Union Medical College Hospital)
Integrated modeling and simulation in support of early clinical development of new drugs in China: case studies
9:50-10:15 Lushan Yu (Zhejiang University, China) 
Epigenetic activation of the drug transporters in cancer cells




 
Session 8 (9:00-10:15)(Location: Hall 139)
Drug metabolism mediated efficacy and adverse effects
Chairs: Yong Hee Choi and Cai-sheng Wu
9:00-9:25 Young Hee Choi (Dongguk University, South Korea)
Drug interaction of metformin and Scutellariae radix in mice
9:25-9:50 Xiaoqiang Xiang (Fudan University, China) 
Application of PBPK in patient treatment to improve efficacy
9:50-10:15 Lan Tang (Southern Medical University, China)
Regulation of metabolic enzymes by oridonin and its detoxification effect on LPS-induced liver injury based on RNA-seq/WGCNA analysis
 
Session 9 (10:15 - 11:30)
Application of advanced drug metabolism models
Chairs:  Sandhya Mandlekar and Yan Yang
10:15-10:40

Xin Wang (East China Normal University)

 Characterization and application of novel P450 knockout rat models

10:40-11:05 Sandhya Mandlekar (BMS in India)
Animal Models in the prediction of drug-drug interaction potential of new chemical entities
11:05-11:30 Guangbo Ge (Shanghai University of Chinese Medicine)
Optical probe substrates for drug metabolizing enzymes:design principle and applications


Session 10 (10:15 - 11:30) 
Analytical technology for ADME studies of new drug platforms 
Chairs: Mingshe Zhu and Kenji Yahata
10:15-10:40 Haifeng Song Song (Beijing National Proteomics Research Center)
Dispostion of cell therpeutics
10:40-11:05 Kenji Yahata (Sanofi Japan)
Direct quantitation of drugs in organelles from living cell by mass-spectrometry
11:05-11:30 Mingshe Zhu (MassDefect Technologies, USA)
Novel approach for study of exposure and disposition of herbal medicines
11:30-11:45 (young speaker)
 
11:45-12:00 Closing Ceremony(Location: Hall 225)
  Closing words by Zeng Su and Zhuohan Hu
  Closing words by CSSX President
  Closing words by ISSX President
Home VIPs/Speakers Agenda Poster Submission Sponsor Registration Accommodation Transportation

College of Pharmaceutical Sciences, Zhejiang University (Zijingang Campus),
No. 866, Yuhangtang Road, West Lake District, Hangzhou City, Zhejiang Province, China

Tel.: +86-21-50800743            Contact: Felton LIN          Email: linyf@rild-biotech.com